A real-world study on clinical predictors of relapse after hospitalized detoxification in a Chinese cohort with alcohol dependence

PeerJ

article

Yu-Jie Tao¹  Li Hu¹  Ying He¹  Bing-Rong Cao¹  Juan Chen¹  Ying-Hua Ye¹  Ting Chen¹  Xia Yang¹  Jia-Jun Xu¹  Jing Li¹  Ya-Jing Meng¹  Tao Li¹  Wan-Jun Guo¹ 

[1] Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan University

关键词: Alcohol dependence;    Relapse;    Real-world study;    Psychotherapy;    Pharmaceutical treatment;   

DOI  :  10.7717/peerj.7547

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundThe relapse rate of alcohol dependence (AD) after detoxification is high, but few studies have investigated the clinical predictors of relapse after hospitalized detoxification in real-world clinical practice, especially among Chinese patients.MethodsThis longitudinal cohort study followed up 122 AD patients who were discharged from January 1, 2016 to January 30, 2018 from their most recent hospitalization for detoxification. These patients were interviewed by telephone from May 20, 2017, to June 30, 2018, at least 6 months after discharge. During the interview, the relapse were assessed by using a revised Chinese version of the Alcohol Use Disorder Identification Test. Candidate predictors, such as therapeutic modalities during hospitalization and at discharge, medical history data related to alcohol use, and demographic information, were obtained from the medical records in the hospital information system.ResultsDuring the 6–24 months (with a median of 9 months) follow-up period, the relapse rate was 53.3%. Individuals with a college education level and those who had not been treated with the brief comprehensive cognitive-motivational-behavioural intervention (CCMBI) were more likely than their counterparts to relapse after hospitalized detoxification, and their adjusted HRs (95% CIs) were 1.85 (1.09, 3.16) and 2.00 (1.16, 3.46), respectively. The CCMBI use predicted a reduction in the relapse rate by approximately one-fifth.ConclusionUndergoing the CCMBI during detoxification hospitalization and having less than a college-level education could predict a reduced risk of AD relapse. These findings provide useful information both for further clinical research and for real-world practice.

【 授权许可】

CC BY