The association between serum lipids and risk of premature mortality in Latin America: a systematic review of population-based prospective cohort studies

PeerJ

article

Rodrigo M. Carrillo-Larco¹  Leonardo Albitres-Flores²  Noël C. Barengo⁶  Antonio Bernabe-Ortiz² 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London;CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia;Centro de Estudios de Población, Universidad Católica los Ángeles de Chimbote;Facultad de Medicina, Universidad Nacional de Trujillo;Sociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo-SOCEMUNT;Department of Medical and Population Health Sciences Research, Herbert Wertheim College of Medicine, Florida International University;Department of Public Health, Faculty of Medicine, University of Helsinki;Faculty of Medicine, Rı¯ga Stradiņš University;Universidad Científica del Sur

关键词: Dyslipidaemias;    Cholesterol;    Survival;    Latin America;   

DOI  :  10.7717/peerj.7856

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectiveTo synthetize the scientific evidence on the association between serum lipids and premature mortality in Latin America (LA).MethodsFive data bases were searched from inception without language restrictions: Embase, Medline, Global Health, Scopus and LILACS. Population-based studies following random sampling methods were identified. The exposure variable was lipid biomarkers (e.g., total, LDL- or HDL- cholesterol). The outcome was all-cause and cause-specific mortality. The risk of bias was assessed following the Newcastle-Ottawa criteria. Results were summarized qualitatively.ResultsThe initial search resulted in 264 abstracts, five (N = 27,903) were included for the synthesis. Three papers reported on the same study from Puerto Rico (baseline in 1965), one was from Brazil (1996) and one from Peru (2007). All reports analysed different exposure variables and used different risk estimates (relative risks, hazard ratios or odds ratios). None of the reviewed reports showed strong association between individual lipid biomarkers and all-cause or cardiovascular mortality.ConclusionThe available evidence is outdated, inconsistently reported on several lipid biomarker definitions and used different methods to study the long-term mortality risk. These findings strongly support the need to better ascertain the mortality risk associated with lipid biomarkers in LA.

【 授权许可】

CC BY