Refractory ascites—the contemporary view on pathogenesis and therapy

PeerJ

article

Beata Kasztelan-Szczerbinska¹  Halina Cichoz-Lach¹ 

[1] Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin

关键词: Refractory ascites;    Liver crirrhosis;    Diuretics;    Paracentesis;    Treatment;   

DOI  :  10.7717/peerj.7855

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Refractory ascites (RA) refers to ascites that cannot be mobilized or that has an early recurrence that cannot be prevented by medical therapy. Every year, 5–10% of patients with liver cirrhosis and with an accumulation of fluid in the peritoneal cavity develop RA while undergoing standard treatment (low sodium diet and diuretic dose up to 400 mg/day of spironolactone and 160 mg/day of furosemide). Liver cirrhosis accounts for marked alterations in the splanchnic and systemic hemodynamics, causing hypovolemia and arterial hypotension. The consequent activation of renin-angiotensin and sympathetic systems and increased renal sodium re-absorption occurs during the course of the disease. Cirrhotic patients with RA have poor prognoses and are at risk of developing serious complications. Different treatment options are available, but only liver transplantation may improve the survival of such patients.

【 授权许可】

CC BY