Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China

PeerJ

article

Jiankui Liu¹  Chunhua Wei¹  Zhifeng Lin³  Wei Xia¹  Ying Ma¹  Ailing Dai¹  Xiaoyan Yang¹ 

[1] College of Life Sciences, Longyan University;Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan University;College of Animal Science, Fujian Agriculture and Forestry University

关键词: PRRSV;    Genome sequence;    1-7-4;    Molecular characteristic;   

DOI  :  10.7717/peerj.7859

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 1-7-4. Additionally, FJ0908 had a 100 aa deletion (aa329–428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China.

【 授权许可】

CC BY