Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice

PeerJ

article

Tunyu Jian¹  Han Lü¹  Xiaoqin Ding¹  Yuexian Wu¹  Yuanyuan Zuo¹  Jiawei Li¹  Jian Chen¹  Hong Gu³ 

[1] Institute of Botany, Jiangsu Province and Chinese Academy of Sciences;Department of Food Science and Technology, College of Light Industry and Food Engineering, Nanjing Forestry University;Department of Colorectal Surgery, Jiangyin Hospital of Traditional Chinese Medicine

关键词: Polyphenol;    Trapa quadrispinosa pericarp;    Non-alcoholic fatty liver disease;    High-fat diet;    AMPK/SREBP/ACC;    IRs-1/Akt;   

DOI  :  10.7717/peerj.8165

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

In China, Trapa quadrispinosa (also called water caltrop) has long been used as a function food and folk medicine to treat diabetes mellitus for years. In the present study, the extract of T. quadrispinosa pericarp (TQPE) which mainly contains hydrolysable tannins was prepared to investigate the potential therapeutic action in non-alcoholic fatty liver disease (NAFLD) mice induced by high fat-diet (HFD). After the administration of TQPE (15, 30 mg/kg/day) for 8 weeks, the increased weight of body and liver were significantly suppressed. TQPE also ameliorated liver lipid deposition and reduced lipids parameters of blood in mice. Moreover, TQPE attenuated oxidative stress and showed a hepatoprotective effect in mice. TQPE was also found to decrease the value of homeostatic model assessment for insulin resistance. In addition, TQPE administration increased the phosphorylation of AMP-activated protein kinase (AMPK) and Acetyl-CoA carboxylase (ACC) and inhibited sterol regulatory element-binding protein (SREBP) in the liver tissue. Meanwhile, TQPE elevated insulin receptor substrate-1 (IRs-1) and protein kinase B (Akt) phosphorylation. These results reflected that, as a nature product, TQPE is a potential agent for suppressing the process of NAFLD via regulation of the AMPK/SREBP/ACC and IRs-1/Akt pathways.

【 授权许可】

CC BY