Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma

PeerJ

article

Qiu Shen¹  Chao Lu¹  Hua Yang⁴  Ming-Xia Ge²  Wang-Xiao Xia²  Qing-Peng Kong²  Gong-Hua Li²  Yan-Hong Gu¹ 

[1] Department of Oncology, The First Affiliated Hospital of Nanjing Medical University;State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences;Department of Oncology, Jiangyin People’s Hospital;The Third People’s Hospital of Yunnan Province

关键词: Colon adenocarcinoma;    Non-mucin-producing colon adenocarcinoma;    Metabolism;    Histological subtype;    Prognosis;    Weighted gene co-expression network analysis (WGCNA);    Glycerophosphodiester phosphodiesterase 1;   

DOI  :  10.7717/peerj.8421

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Colon adenocarcinoma (COAD) represents a major public health issue due to its high incidence and mortality. As different histological subtypes of COAD are related to various survival outcomes and different therapies, finding specific targets and treatments for different subtypes is one of the major demands of individual disease therapy. Interestingly, as these different subtypes show distinct metabolic profiles, it may be possible to find specific targets related to histological typing by targeting COAD metabolism. In this study, the differential expression patterns of metabolism-related genes between COAD (n = 289) and adjacent normal tissue (n = 41) were analyzed by one-way ANOVA. We then used weighted gene co-expression network analysis (WGCNA) to further identify metabolism-related gene connections. To determine the critical genes related to COAD metabolism, we obtained 2,114 significantly differentially expressed genes (DEGs) and 12 modules. Among them, we found the hub module to be significantly associated with histological typing, including non-mucin-producing colon adenocarcinoma and mucin-producing colon adenocarcinoma. Combining survival analysis, we identified glycerophosphodiester phosphodiesterase 1 (GDE1) as the most significant gene associated with histological typing and prognosis. This gene displayed significantly lower expression in COAD compared with normal tissues and was significantly correlated with the prognosis of non-mucin-producing colon adenocarcinoma (p = 0.0017). Taken together, our study showed that GDE1 exhibits considerable potential as a novel therapeutic target for non-mucin-producing colon adenocarcinoma.

【 授权许可】

CC BY