Recent advances in the contribution of noncoding RNAs to cisplatin resistance in cervical cancer

PeerJ

article

Xin Wen¹  Shui Liu¹  Jiyao Sheng¹  Manhua Cui¹ 

[1] The Second Hospital of Jilin University, Jilin University, Changchun, Jilin Province

关键词: Cervical cancer;    Cisplatin resistance;    MicroRNA;    Long non-coding RNA;    Circular RNA;    Noncoding RNAs;   

DOI  :  10.7717/peerj.9234

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Cervical cancer (CC) remains a major disease burden on the female population worldwide. Chemotherapy with cisplatin (cis-diamminedichloroplatinum (II); CDDP) and related drugs are the main treatment option for CC; however, their efficacy is limited by the development of drug resistance. Noncoding RNAs (ncRNAs) have been found to play critical roles in numerous physiological and pathological cellular processes, including drug resistance of cancer cells. In this review, we describe some of the ncRNAs, including miRNAs, lncRNAs and circRNAs, that are involved in the sensitivity/resistance of CC to CDDP-based chemotherapy and discuss their mechanisms of action. We also describe some ncRNAs that could be therapeutic targets to improve the sensitivity of CC to CDDP-based chemotherapy.

【 授权许可】

CC BY