Association of impaired fasting glucose and Type 2 Diabetes Mellitus with brain volume changes in Alzheimer’s Disease patients analyzed by MRI: a retrospective study

PeerJ

article

Weiwei Wang¹  Leongtim Wong³  Lin Shi⁴  Yishan Luo³  Zhanhua Liang⁵  Chunbo Dong⁵  Qingwei Song²  Tieli Liu²  Qing Zhang⁶  Ailian Liu²  Yanwei Miao²  Jianlin Wu⁶ 

[1] Tianjin Medical University;Radiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province;BrainNow Research Institute, Shenzhen, Guangdong Province;Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong;Neurology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province;Radiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province

关键词: Alzheimer’s disease;    Impaired fasting glucose;    Type 2 diabetes mellitus;    Brain volume;    Structural MRI;    Brain atrophy;    Pons;    Fasting glucose level;    Hyperglycemia;   

DOI  :  10.7717/peerj.9801

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectivesAlzheimer’s disease (AD), impaired fasting glucose (IFG), and Type 2 diabetes mellitus (T2DM) were reported associated with smaller brain volumes. Nevertheless, the association of hyperglycemia with brain volume changes in AD patients remains unclear. To investigate this issue, structural magnetic resonance imaging was used to compare brain volumes among AD patients with different fasting glucose levels.MethodsEighty-five AD patients were divided into three groups based on their fasting glucose level as suggested by the American Diabetes Association: normal fasting glucose group (AD_NFG, n = 45), AD_IFG group (n = 15), and AD_T2DM group (n = 25). Sagittal 3D T1-weighted images were obtained to calculate the brain volume. Brain parenchyma and 33 brain structures were automatically segmented. Each regional volume was analyzed among groups. For regions with statistical significance, partial correlation analysis was used to evaluate their relationships with fasting glucose level, corrected for Mini-Mental State Examination score, age, education level, cholesterol, triglyceride, and blood pressure.ResultsCompared with the AD_IFG and AD_NFG groups, the volume of pons in AD_T2DM group was significantly smaller. Fasting glucose was negatively correlated with pontine volume.ConclusionsT2DM may exacerbate pontine atrophy in AD patients, and fasting glucose level is associated with pontine volume.

【 授权许可】

CC BY