Correlation between obesity and clinicopathological characteristics in patients with papillary thyroid cancer: a study of 1579 cases: a retrospective study

PeerJ

article

Huijuan Wang¹  Pingping Wang²  Yu Wu³  Xiukun Hou¹  Zechun Peng⁴  Weiwei Yang⁵  Lizhao Guan⁶  Linfei Hu¹  Jingtai Zhi¹  Ming Gao¹  Xiangqian Zheng¹ 

[1] Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer;Department of Thyroid and Breast Surgery, Rizhao Central Hospital;Department of Head and Neck Surgery, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital;Department of Urology Surgery, AreaII, The Second Affiliated Hospital of Hainan Medical University;Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital;Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University

关键词: Body mass index;    Papillary thyroid cancer;    Correlation;   

DOI  :  10.7717/peerj.9675

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectiveTo explore the relationship between body mass index (BMI) and clinicopathological characteristics in patients with papillary thyroid carcinoma (PTC).MethodsThe clinical data of 1,579 patients with PTC, admitted to our hospital from May 2016 to March 2017, were retrospectively analyzed. According to the different BMI of patients, it can be divided into underweight recombination (BMI < 18.5 kg/m), normal body recombination (18.5 ≤ BMI < 24.0 kg/m2), overweight recombination (24.0 ≤ BMI < 28.0 kg/m2) and obesity group (BMI ≥ 28.0 kg/m2). The clinicopathological characteristics of PTC in patients with different BMIs group were compared.ResultsIn our study, the risk for extrathyroidal extension (ETE), advanced T stage (T III/IV), and advanced tumor-node-metastasis stage (TNM III/IV) in the overweight group were higher, with OR (odds ratio) = 1.99(1.41–2.81), OR = 2.01(1.43–2.84), OR = 2.94(1.42–6.07), respectively, relative to the normal weight group. The risk for ETE and T III/IV stage in the obese group were higher, with OR = 1.82(1.23–2.71) and OR = 1.82(1.23–2.70), respectively, relative to the normal weight group.ConclusionBMI is associated with the invasiveness of PTC. There is a higher risk for ETE and TNM III/IV stage among patients with PTC in the overweight group and for ETE among patients with PTC in the obese group.

【 授权许可】

CC BY