Identifying myocardial injuries in “normal-appearing” myocardium in pediatric patients with clinically suspected myocarditis using mapping techniques

PeerJ

article

Haipeng Wang¹  Bin Zhao²  Huan Yang¹  Tianyi Qian³  Bo Han⁴  Haipeng Jia⁵  Jing An⁶  Junyu Zhao⁷  Ximing Wang¹  Cuiyan Wang² 

[1] Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University;Shandong Medical Imaging Research Institute Affiliated to Shandong University;Siemens Healthcare, MR Collaborations NE Asia;Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University;Department of Radiology, Qilu Hospital of Shandong University;Siemens SSMR;Division of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital

关键词: Cardiac magnetic resonance;    Mapping techniques;    Pediatric myocarditis;    Diffuse myocardial injuries;   

DOI  :  10.7717/peerj.10252

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundMapping techniques using cardiac magnetic resonance imaging have significantly improved the diagnostic accuracy for myocarditis with focal myocardial injuries. The aim of our study was to determine whether T1 and T2 mapping techniques could identify diffuse myocardial injuries in “normal-appearing” myocardium in pediatric patients with clinically suspected myocarditis and to evaluate the associations between diffuse myocardial injuries and cardiac function parameters.MethodsForty-six subjects were included in this study: 20 acute myocarditis patients, 11 subacute/chronic myocarditis patients and 15 control children. T2 values, native T1 values and the extracellular volume (ECV) of “normal-appearing” myocardium were compared among the three groups of patients. Associations between diffuse myocardial injuries and cardiac function parameters were also evaluated.ResultsThe ECV of “normal-appearing” myocardium was significantly higher in the subacute/chronic myocarditis group than in the control group (30.1 ± 0.9 vs 27.0 ± 0.6, P =0.004). No significant differences in T1 and T2 values between the acute myocarditis and control groups were found. In the subacute/chronic myocarditis group, a significant association between ECV and left ventricle ejection fraction was found (P=0.03).ConclusionsDiffuse myocardial injuries are likely to occur in subacute/chronic myocarditis patients with prolonged inflammatory responses. Mapping techniques have great value for the diagnosis and monitoring of myocarditis.

【 授权许可】

CC BY