Characteristics and outcomes of hemodialysis patients with COVID-19: a retrospective single center study

PeerJ

article

Yongwen Luo¹  Junli Li²  Zhifen Liu³  Heping Yu⁴  Xiang Peng⁵  Cheng’an Cao⁵ 

[1] Department of Urology, Zhongnan Hospital of Wuhan University;Institute of Laboratory Animal Sciences, Peking Union Medical College;Department of Nephrology, Wuhan Fourth Hospital;Department of Thyroid and Breast Surgery, Wuhan Fourth Hospital;Department of Neurology, Wuhan Fourth Hospital

关键词: COVID-19;    Coronavirus;    SARS-CoV-2;    Hemodialysis;   

DOI  :  10.7717/peerj.10459

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background The coronavirus 19 (COVID-19) pandemic has heightened the threat to the health and lives of patients with comorbid diseases. Infection by COVID-19 is especially detrimental to patients on hemodialysis. In this study, we evaluated the clinical characteristics, laboratory findings, treatments and prognoses of hemodialysis patients with COVID-19. Methods A total of 16 hemodialysis patients with COVID-19 were recruited from Wuhan Fourth Hospital from 5 February to 20 March 2020 for a retrospective, single-center study. A total of 62 non-dialysis patients with COVID-19 were the control group. We collected data on the clinical characteristics, laboratory findings, treatments, and clinical outcomes of patients affected by the virus. Results Hemodialysis patients with COVID-19 had a lower incidence of fever (P = 0.001) and relatively higher incidence of pre-admission comorbidities and shortness of breath than non-dialysis patients with COVID-19 (75% vs. 61%, P = 0.467 50% vs. 33.87%, P = 0.248 ). Hemodialysis patients had lower levels of hemoglobin (P < 0.001), white blood cell counts (P = 0.015), neutrophils (P = 0.016), AST (P = 0.037), ALT (P < 0.001) and procalcitonin (P < 0.001), and higher levels of D-dimer (P < 0.001) and thrombin time (P < 0.001). Hemodialysis patients had a higher incidence of pulmonary effusion, cord-like high-density shadows, pleural thickening, and atelectasis (P < 0.05). Hemodialysis patients also had relatively higher rates of mortality and prolonged hospital stays compared with the control group. Conclusions Hemodialysis patients typically present with multiple comorbidities and are considered to be a high-risk group for COVID-19 infections. Hemodialysis patients with COVID-19 may have prolonged hospital stays and unfavorable prognoses and should be closely monitored.

【 授权许可】

CC BY