Partial restoration of normal intestinal microbiota in morbidly obese women six months after bariatric surgery

PeerJ

article

Jukka Koffert¹  Leo Lahti³  Lotta Nylund⁴  Seppo Salminen⁴  Jarna C. Hannukainen²  Paulina Salminen⁶  Willem M. de Vos⁷  Pirjo Nuutila² 

[1] Department of Gastroenterology, Turku University Hospital;Turku PET Centre, University of Turku;Department of Mathematics and Statistics, University of Turku;Functional Foods Forum, University of Turku;Food Chemistry and Food Development, Department of Biochemistry, University of Turku;Division of Digestive Surgery and Urology, Turku University Hospital;RPU Immunobiology and Human Microbiome, University of Helsinki;Laboratory of Microbiology, Wageningen University and Research;Department of Endocrinology, Turku University hospital

关键词: Fecal microbiota;    Bariatric surgery;    Type 2 diabetes;    Obesity;    Clinical trial;   

DOI  :  10.7717/peerj.10442

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

We studied the impact of bariatric surgery on the intestinal microbiota of morbidly obese study subjects. A total of 13 morbidly obese women (five of which had type 2 diabetes) and 14 healthy age- and gender-matched controls were recruited and the microbiota composition of fecal samples were determined by using a phylogenetic microarray. Sampling of the patients took place just one month before and 6 months after the operation. Within six months after bariatric surgery, the obese subjects had lost on average a quarter of their weight whereas four of the five of the diabetic subjects were in remission. Bariatric surgery was associated with an increased microbial community richness and Bacteroidetes/Firmicutes ratio. In addition, we observed an increased relative abundance of facultative anaerobes, such as Streptococcus spp., and a reduction in specific butyrate-producing Firmicutes. The observed postoperative alterations in intestinal microbiota reflect adaptation to the changing conditions in the gastrointestinal tract, such as energy restriction and the inability to process fiber-rich foods after bariatric surgery.

【 授权许可】

CC BY