Long-term administration of vitamin B12 and adenosine triphosphate for idiopathic sudden sensorineural hearing loss: a retrospective study

PeerJ

article

Takaomi Kurioka¹  Hajime Sano²  Shogo Furuki¹  Taku Yamashita¹ 

[1]Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University

[2]School of Allied Health Sciences, Kitasato University

关键词: Vitamin B12;    Adenosine triphosphate;    Idiopathic sudden sensorineural hearing loss;    Administration duration;    Hearing recovery;   

DOI  :  10.7717/peerj.10406

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundIn idiopathic sudden sensorineural hearing loss (ISSNHL), the relationship between the administration duration of vitamin B12 (vit B12) with adenosine triphosphate (ATP) and their therapeutic effect is not fully understood.ObjectiveTo investigate the therapeutic effect of long-term 16 (≥weeks) administration of vit B12 with ATP on the prognosis of ISSNHL patients and compare it with those of short-term (<8 weeks) and middle-term (≥8 weeks, <16 weeks) administration.MethodsWe retrospectively reviewed the medical records of 117 patients with ISSNHL treated between 2015 and 2018.ResultsThe overall recovery rate was 32.5%. Initial higher hearing threshold and initial higher grade of hearing loss (HL) were associated with a poor prognosis. However, the administration duration of vit B12 and ATP did not influence the overall hearing improvement. With regard to the time course of hearing recovery, there was no significant difference in hearing recovery among the long-, middle-, and short-term administration groups until 16 weeks after treatment. However, at 16–24 weeks after initial treatment, the short-term administration group exhibited significantly lower hearing recovery than did the long-term administration groups.ConclusionsThe administration duration of vit B12 and ATP did not influence the overall hearing prognosis in ISSNHL, but long-term administration of vit B12 and ATP helped prevent the progression of HL after ISSNHL. Our results suggest that long-term administration of vit B12 and ATP is not necessarily required to treat ISSNHL patients, except for slowly progressing HL in the affected ears.

【 授权许可】

CC BY