Comparison of gut microbiota between adults with autism spectrum disorder and obese adults

PeerJ

article

Qiang Zhang¹  Rong Zou²  Min Guo²  Mengmeng Duan²  Quan Li¹  Huajun Zheng² 

[1] Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University;NHC Key Lab. of Reproduction Regulation ,(Shanghai Institute of Planned Parenthood Research), Fudan University

关键词: Autism spectrum disorder;    Obesity;    Gut microbiota;    Adult autism spectrum disorder;    16S rRNA;   

DOI  :  10.7717/peerj.10946

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundAutism spectrum disorder (ASD) and obesity are serious global public health problems. Studies have shown that ASD children are at a higher risk of obesity than the general population. To investigate the gut microbe characteristics of adults ASD and obese adults, we compared the gut microbiota of adults with ASD to obese adults.MethodsThe fecal samples were collected from 21 adult patients with ASD and 21 obese adults, and V3–V4 regions of 16S rRNA genes were sequenced by high-throughput DNA sequencing. The gut microbiota of adults with ASD and obese adults was compared.ResultsWe observed the proportion of Firmicutes/Bacteroidetes in ASD was significantly increased, with families Lachnospiraceae and Ruminococcaceae significantly enriched in adult ASD. Eighteen genera, including Lachnospiracea incertae sedis, Ruminococcus, Blautia, and Holdemanella were significantly increased in adult ASD, whereas Megamonas and Fusobacterium were significantly increased in obesity. At the species level, we found six species enriched in ASD and three species enriched in obesity, including Phascolarctobacterium succinatuten producing propionate. Dialister succinatiphilus may be as a biomarker for predicting obesity, as well as Prevotella copri may be a common-owned pathogens of ASD and obesity.ConclusionsSome conflicting results have been reported in microbiota studies of ASD, which may be related to age and obesity. Thus, the body mass index should be evaluated before analyzing the gut microbiota of patients with ASD, as obesity is prevalent in these individuals and gut microbiota is severally affected by obesity.

【 授权许可】

CC BY