Direct-acting antiviral treatment for Hepatitis C Virus in geriatric patients: a real-world retrospective comparison between early and late elderly patients

PeerJ

article

Hsu-Heng Yen¹  Pei-Yuan Su¹  I-Ling Liu¹  Ya-Yuei Zeng¹  Siou-Ping Huang¹  Yu-Chun Hsu¹  Chia-Wei Yang¹  Yang-Yuan Chen¹ 

[1] Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital;General Educational Center, Chienkuo Technology University;Institute of Medicine, Chung Shan Medical and Dental College

关键词: Hepatitis C;    Geriatric;    Viral hepatitis;    Direct-acting antiviral treatment;   

DOI  :  10.7717/peerj.10944

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

IntroductionChronic hepatitis C virus (HCV) infection rates are high in the geriatric population considering that interferon-based therapy is usually intolerable. With the introduction of oral antiviral therapy for HCV, increased treatment tolerability and good treatment responses have been observed. However, treatment data regarding the geriatric population have been limited. Therefore, this retrospective study aimed to evaluate the efficacy and safety of direct-acting antiviral therapy for HCV in the geriatric population.Materials and MethodsThe primary end point was sustained virologic response (SVR) 12 weeks after treatment completion, whereas the secondary end points were treatment-related side effects and short-term survival rate following treatment.ResultsIn total, 492 patients (median age, 73 years; 43.9% males), including 278 early elderly patients, were enrolled. Among the included patients, 45% had cirrhosis. HCV genotypes 1 (72.4%) and 2 (25.4%) were the most common. The overall SVR rate was 96.7%, with no difference in SVR rates observed between early and late elderly groups (96.8% vs. 96.7%; p = 0.983). Both groups showed similar side effects, including dizziness (11.4%), and fatigue (8.7%), with three patients discontinuing therapy owing to side effects. Both groups had a similar 3-year survival rate. Significant factors associated with post-treatment survival included cirrhosis, albumin, and creatinine level.ConclusionsOur real-world data showed that both early and late elderly patients could undergo direct-acting antiviral treatment for HCV with excellent treatment outcomes.

【 授权许可】

CC BY