Plasma BDNF concentrations and the antidepressant effects of six ketamine infusions in unipolar and bipolar depression

PeerJ

article

Wei Zheng¹  Yan-Ling Zhou¹  Cheng-Yu Wang¹  Xiao-Feng Lan¹  Bin Zhang¹  Su-Miao Zhou¹  Su Yan¹  Yu-Ping Ning¹ 

[1] Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University ,(Guangzhou Huiai Hospital);Psychiatry, The first School of Clinical Medicine, Southern Medical University

关键词: Ketamine;    Brain-derived neurotrophic factor;    Depression;    Predictors;    Response;   

DOI  :  10.7717/peerj.10989

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

ObjectivesAccumulating evidence has implicated that brain derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of depression, but its correlation with ketamine’s antidepressant efficacy focusing on Chinese individuals with depression is not known. This study was aim to determine the correlation of plasma BDNF (pBDNF) concentrations and ketamine’s antidepressant efficacy.MethodsNinety-four individuals with depression received six intravenous infusions ketamine (0.5 mg/kg). Remission and response were defined as Montgomery-Asberg Depression Rating Scale (MADRS) scores less than 10 and a reduction of 50% or more in MADRS scores, respectively. Plasma was collected at baseline and at 24 h and 2 weeks after completing six ketamine infusions (baseline, 13 d and 26 d).ResultsA significant improvement in MADRS scores and pBDNF concentrations was found after completing six ketamine infusions compared to baseline (all ps < 0.05). Higher baseline pBDNF concentrations were found in ketamine responders/remitters (11.0 ± 6.2/10.1 ± 5.8 ng/ml) than nonresponders/nonremitters (8.0 ± 5.5/9.2 ± 6.4 ng/ml) (all ps < 0.05). Baseline pBDNF concentrations were correlated with MADRS scores at 13 d (t =  − 2.011, p = 0.047) or 26 d (t =  − 2.398, p = 0.019) in depressed patients (all ps < 0.05). Subgroup analyses found similar results in individuals suffering from treatment refractory depression.ConclusionThis preliminary study suggests that baseline pBDNF concentrations appeared to be correlated with ketamine’s antidepressant efficacy in Chinese patients with depression.

【 授权许可】

CC BY