Temporal inversion of the acid-base equilibrium in newborns: an observational study

PeerJ

article

Yuko Mizutani¹  Masahiro Kinoshita²  Yung-Chieh Lin³  Satoko Fukaya¹  Shin Kato¹  Tadashi Hisano¹  Hideki Hida⁴  Sachiko Iwata¹  Shinji Saitoh¹  Osuke Iwata¹ 

[1] Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences;Department of Paediatrics and Child Health, Kurume University School of Medicine;Department of Pediatrics, National Cheng-Kung University;Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medicine

关键词: Acid-base balance;    Newborn and infant;    Postnatal adaption;    Blood gas analysis;    Physiology;   

DOI  :  10.7717/peerj.11240

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundA considerable fraction of newborn infants experience hypoxia-ischaemia and metabolic acidosis at birth. However, little is known regarding the biological response of newborn infants to the pH drift from the physiological equilibrium. The aim of this study was to investigate the relationship between the pH drift at birth and postnatal acid-base regulation in newborn infants.MethodsClinical information of 200 spontaneously breathing newborn infants hospitalised at a neonatal intensive care centre were reviewed. Clinical variables associated with venous blood pH on days 5–7 were assessed.ResultsThe higher blood pH on days 5–7 were explained by lower cord blood pH (−0.131, −0.210 to −0.052; regression coefficient, 95% confidence interval), greater gestational age (0.004, 0.002 to 0.005) and lower partial pressure of carbon dioxide on days 5–7 (−0.005, −0.006 to −0.004) (adjusted for sex, postnatal age and lactate on days 5–7).ConclusionIn relatively stable newborn infants, blood pH drift from the physiological equilibrium at birth might trigger a system, which reverts and over-corrects blood pH within the first week of life. Given that the infants within the study cohort was spontaneously breathing, the observed phenomenon might be a common reaction of newborn infants to pH changes at birth.

【 授权许可】

CC BY