Evaluating active versus passive sources of human brucellosis in Jining City, China

PeerJ

article

Xihong Sun¹  Wenguo Jiang²  Yan Li²  Xiuchun Li³  Qingyi Zeng⁴  Juan Du⁵  Aitian Yin¹  Qing-Bin Lu⁵ 

[1] Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, NHC Key Laboratory of Health Economics and Policy Research ,(Shandong University);Jining Center for Disease Control and Prevention;Liangshan Center for Disease Control and Prevention;Yutai Center for Disease Control and Prevention;Laboratorial Science and Technology, School of Public Health, Peking University;Center for Infectious Disease Research and Policy, Peking University Institute for Global Health

关键词: Human brucellosis;    Active and passive sources;    Contact history;    China;   

DOI  :  10.7717/peerj.11637

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Human brucellosis (HB) remains a serious public health concern owing to its resurgence across the globe and specifically in China. The timely detection of this disease is the key to its prevention and control. We sought to describe the differences in the demographics of high-risk populations with detected cases of HB contracted from active versus passive sources. We collected data from a large sample population from January to December 2018, in Jining City, China. We recruited patients that were at high-risk for brucellosis from three hospitals and Centers of Disease Control and Prevention (CDCs). These patients were classified into two groups: the active detection group was composed of individuals receiving brucellosis counseling at the CDCs; the passive detection group came from hospitals and high-risk HB groups. We tested a total of 2,247 subjects and 13.3% (299) presented as positive for HB. The positive rates for active and passive detection groups were 20.5% (256/1,249) and 4.3% (43/998), respectively (p < 0.001). The detection rate of confirmed HB cases varied among all groups but was higher in the active detection group than in the passive detection group when controlled for age, sex, ethnicity, education, career, and contact history with sheep or cattle (p < 0.05). Males, farmers, those with four types of contact history with sheep or cattle, and those presenting fever, hyperhidrosis and muscle pain were independent factors associated with confirmed HB cases in multivariate analysis of the active detection group. Active detection is the most common method used to detect brucellosis cases and should be applied to detect HB cases early and avoid misdiagnosis. We need to improve our understanding of brucellosis for high-risk populations. Passive HB detection can be supplemented with active detection when the cognitive changes resulting from brucellosis are low. It is important that healthcare providers understand and emphasis the timely diagnosis of HB.

【 授权许可】

CC BY