Bioactive marine metabolites derived from the Persian Gulf compared to the Red Sea: similar environments and wide gap in drug discovery

PeerJ

article

Reham K. Abuhijjleh¹  Samiullah Shabbir¹  Ahmed M. Al-Abd¹  Nada H. Jiaan¹  Shahad Alshamil¹  Eman M. El-labbad¹  Sherief I. Khalifa¹ 

[1] Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University;Pharmacology Department, Medical Division, National Research Centre;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University

关键词: Marine metabolites;    Red sea;    Gulf of Oman;    Fauna;    Aspergillus sp.;    Persian Gulf;    Arabian Gulf;   

DOI  :  10.7717/peerj.11778

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Marine life has provided mankind with unique and extraordinary chemical structures and scaffolds with potent biological activities. Many organisms and secondary metabolites derived from fungi and symbionts are found to be more environmentally friendly to study than the marine corals per se. Marine symbionts such as Aspergillus sp., a fungus, which can be isolated and grown in the lab would be a potential and continuous source of bioactive natural compounds without affecting the marine environment. The Red Sea is known for its biodiversity and is well-studied in terms of its marine-derived bioactive metabolites. The harsh environmental conditions lead to the development of unique metabolic pathways. This, in turn, results in enhanced synthesis and release of toxic and bioactive chemicals. Interestingly, the Persian Gulf and the Gulf of Oman carry a variety of environmental stresses, some of which are similar to the Red Sea. When compared to the Red Sea, the Persian Gulf has been shown to be rich in marine fungi as well, and is, therefore, expected to contain elaborate and interesting bioactive compounds. Such compounds may or may not be similar to the ones isolated from the Red Sea environment. Astoundingly, there are a very limited number of studies on the bioactive portfolio of marine-derived metabolites from the Persian Gulf and the Gulf of Oman. In this perspective, we are looking at the Red Sea as a comparator marine environment and bioactive materials repertoire to provide a futuristic perspective on the potential of the understudied and possibly overlooked bioactive metabolites derived from the marine life of the Persian Gulf and the Gulf of Oman despite its proven biodiversity and harsher environmental stress.

【 授权许可】

CC BY