Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer

PeerJ

article

Hui Zhao¹  Junjun Zhang³  Xiaoliang Fu⁴  Dongdong Mao¹  Xuesen Qi¹  Shuai Liang¹  Gang Meng¹  Zewen Song³  Ru Yang⁵  Zhenni Guo⁶  Binghua Tong⁶  Meiqing Sun⁶  Baile Zuo⁷  Guoyin Li⁶ 

[1] Department of Urology, Affiliated Hospital of Weifang Medical University;Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University;Department of Oncology, The Third Xiangya Hospital of Central South University;Department of Urology, The Second Affiliated Hospital of Air Force Medical University;Henan Key Laboratory of Neurorestoratology, The First Affliated Hospital of Xinxiang Medical University;College of Life Science and Agronomy, Zhoukou Normal University;Tumor Molecular Immunology and Immunotherapy Laboratory, School of Laboratory Medicine, Xinxiang Medical University;Academy of Medical Science, Zhengzhou University

关键词: NEDD4L;    Bioinformatics;    Clear-cell renal cell cancer;    Prognosis;    Metabolism;   

DOI  :  10.7717/peerj.11880

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

The members of the Nedd4-like E3 family participate in various biological processes. However, their role in clear cell renal cell carcinoma (ccRCC) is not clear. This study systematically analyzed the Nedd4-like E3 family members in ccRCC data sets from multiple publicly available databases. NEDD4L was identified as the only NEDD4 family member differentially expressed in ccRCC compared with normal samples. Bioinformatics tools were used to characterize the function of NEDD4L in ccRCC. It indicated that NEDD4L might regulate cellular energy metabolism by co-expression analysis, and subsequent gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. A prognostic model developed by the LASSO Cox regression method showed a relatively good predictive value in training and testing data sets. The result revealed that NEDD4L was associated with biosynthesis and metabolism of ccRCC. Since NEDD4L is downregulated and dysregulation of metabolism is involved in tumor progression, NEDD4L might be a potential therapeutic target in ccRCC.

【 授权许可】

CC BY