Struo2: efficient metagenome profiling database construction for ever-expanding microbial genome datasets

PeerJ

article

Nicholas D. Youngblut¹  Ruth E. Ley¹ 

[1] Microbiome Science, Max Planck Institute for Developmental Biology

关键词: Metagenome;    Database;    Profiling;    GTDB;   

DOI  :  10.7717/peerj.12198

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

3.5 fold faster than Struo at database generation and can also efficiently update existing databases. We also provide custom Kraken2, Bracken, and HUMAnN3 databases that can be easily updated with new genomes and/or individual gene sequences. Efficient database updating, coupled with our pre-generated databases, enables “assembly-enhanced” profiling, which increases database comprehensiveness via inclusion of native genomic content. Inclusion of newly generated genomic content can greatly increase database comprehensiveness, especially for understudied biomes, which will enable more accurate assessments of microbiome diversity.

【 授权许可】

CC BY