Preclinical models of acute liver failure: a comprehensive review

PeerJ

article

Joshua Hefler¹  Braulio A. Marfil-Garza¹  Rena L. Pawlick¹  Darren H. Freed⁴  Constantine J. Karvellas⁵  David L. Bigam¹  A. M. James Shapiro¹ 

[1] Division of General Surgery, Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta;National Institutes of Medical Sciences & Nutrition Salvador Zubiran;CHRISTUS-LatAm Hub Excellence & Innovation Center;Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine & Dentistry, University of Alberta;Division of Gastroenterology, Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta;Department of Critical Care Medicine, Faculty of Medicine & Dentistry, University of Alberta;Clinical Islet Transplant Program, University of Alberta

关键词: Acute liver failure;    Preclinical models;    Surgical models;    Toxicity models;   

DOI  :  10.7717/peerj.12579

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to study clinically, necessitating reliance on preclinical models as means to explore pathophysiology and novel therapies. Preclinical models of acute liver failure are artificial by nature, and generally fall into one of three categories: surgical, pharmacologic or immunogenic. This article reviews preclinical models of acute liver failure and considers their relevance in modeling clinical disease.

【 授权许可】

CC BY