A novel nutritional index as a predictor of mortality in dilated cardiomyopathy: a retrospective study

PeerJ

article

Can Wang¹  Yali Qing¹  Wuxian Chen¹  Gaoye Li¹ 

[1] Cardiology, The First Affiliated Hospital of Guangxi Medical University

关键词: Dilated cardiomyopathy;    Nutritional index;    Biomarker;    Prognosis;   

DOI  :  10.7717/peerj.12704

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundResearch has associated nutritional status with the prognosis of cardiovascular diseases. This study aimed to investigate the prognostic value of a novel nutritional index, triglycerides × total cholesterol × body weight index (TCBI), in patients with dilated cardiomyopathy (DCM).MethodsThis retrospective cohort study enrolled 445 patients with DCM. The median follow-up period was 2.8 years, and the primary endpoint was all-cause death.ResultsDuring follow-up, the all-cause mortality was observed in 135 out of 445 patients (30.3%). In Kaplan–Meier survival analysis, the third TCBI tertile had a lower mortality risk (T3 vs. T2 vs. T1: 16.9% vs. 35.1% vs. 38.9%; log-rank P < 0.001). In the multivariable Cox regression analysis, patients in the third tertile were associated with a decreased mortality, whereas there was no significant difference between the T2 and T1 groups. Moreover, TCBI could significantly improve risk stratification (continuous net reclassification improvement and integrated discrimination improvement) over the Geriatric Nutritional Risk Index (GNRI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).ConclusionsTCBI is independently associated with long-term survival in patients with DCM. Combination of TCBI and other biomarkers, such as GNRI and NT-proBNP, can significantly improve prognostic prediction. Further studies with larger sample size are required to validate our results.

【 授权许可】

CC BY