Transcription factor 7-like 2 single nucleotide polymorphisms rs290487 and rs290481 are associated with dyslipidemia in the Balinese population

PeerJ

article

Prisca C. Limardi¹  Sukma Oktavianthi¹  Lidwina Priliani¹  Retno Lestari²  Made Ratna Saraswati³  Ketut Suastika³  Safarina G. Malik¹ 

[1] Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, National Research and Innovation Agency;Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia;Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University

关键词: Dyslipidemia;    SNPs;    TCF7L2;    rs290487;    rs290481;    Lipid profiles;   

DOI  :  10.7717/peerj.13149

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Dyslipidemia is one of the major risks for the development of cardiovascular diseases which has been the leading cause of death in developing countries. Previously, common polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been associated with altered lipid profiles. In this study, we investigated the associations of TCF7L2 SNPs, rs290487 and rs290481, with dyslipidemia and altered lipid profile in the Balinese. Methods A total of 565 subjects from four locations in the Bali Province, Indonesia, were recruited. Serum lipid concentrations (triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC)) were measured using standard protocol. SNP genotyping was done using the amplification refractory system mutation polymerase chain reaction (ARMS-PCR) method. Results We found the shifted major/minor allele frequencies of both SNPs (0.56 for rs290487 T allele, 0.53 for rs290481 T allele) in the Balinese, as compared to dbSNP. The rs290487 and rs290481 C alleles were significantly associated with dyslipidemia, particularly high TC and high LDL-C. These associations were independent of age, sex, population, obesity, diabetes mellitus, and high TyG index as a proxy for insulin resistance. The haplotype CC also showed similar association with these traits. Our findings indicate that TCF7L2 polymorphisms are associated with dyslipidemia and altered lipid profile in the Balinese.

【 授权许可】

CC BY