The association of plasma osteoprotegerin levels and functional outcomes post endovascular thrombectomy in acute ischemic stroke patients: a retrospective observational study

PeerJ

article

Moo-Seok Park¹  Jin-Hee Park²  Ahran Joo³  Yoonkyung Chang⁴  Tae-Jin Song¹ 

[1] Department of Neurology, Seoul Hospital Ewha Womans University College of Medicine;Department of Molecular Medicine, College of Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University;Department of Medicine, Ewha Womans University College of Medicine;Department of Neurology, Mokdong Hospital Ewha Womans University College of Medicine

关键词: Osteoprotegerin;    Stroke;    Prognosis;    Endovascular thrombectomy;   

DOI  :  10.7717/peerj.13327

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundOsteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, is a tumor necrosis factor receptor superfamily component. There is an established relationship between OPG and cardiovascular disease. We hypothesized that plasma OPG levels are associated with functional outcomes in acute ischemic stroke patients who have undergone endovascular thrombectomy (EVT).MethodsFrom April 2014 through December 2020, a total of 360 acute ischemic stroke patients who underwent EVT were prospectively included in this retrospective observational study. Plasma OPG was measured after fasting for 12 postoperative hours after EVT. A modified Rankin Scale (mRS) was used to assess functional outcomes 3 months after index stroke occurrence. Univariate and multivariate binary logistic regression and ordinal logistic regression analyses were performed to investigate the association of plasma OPG levels with poor functional outcomes.Results 2) outcomes. The mean ± standard deviation plasma OPG level was 200.2 ± 74.4 pg/mL. Multivariate analysis after adjusting for sex, body mass index, and variables with p < 0.1 in the preceding univariate analysis revealed high plasma OPG levels were independently associated with poor functional outcomes (highest tertile vs. lowest tertile of OPG; odds ratios (OR) 2.121, 95% confidence interval (CI) [1.089–4.191], p = 0.037 in binary logistic regression, OR 2.102, 95% CI [1.301–3.412], p = 0.002 in ordinal logistic regression analysis).ConclusionsThis study demonstrated that higher plasma OPG levels were associated with poor functional outcomes in acute ischemic stroke patients who underwent EVT.

【 授权许可】

CC BY