IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma

PeerJ

article

Siti Muhamad Nur Husna¹  Norasnieda Shukri²  Noor Suryani Mohd Ashari¹  Kah Keng Wong¹ 

[1] Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia;Department of Otorhinolaryngology, School of Medical Sciences, Universiti Sains Malaysia

关键词: IL-4;    IL-13;    IL-4Rα;    IL-13Rα1;    Allergic rhinitis;    Asthma;    Therapeutic antibodies;   

DOI  :  10.7717/peerj.13444

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid. Interleukin (IL)-4 and IL-13 are critical cytokines in the induction of the pathogenic Th2 responses in AR and asthma. Targeting the IL-4/IL-13 axis at various levels of its signaling pathway has emerged as promising targeted therapy in both AR and asthma patient populations. In this review, we discuss the biological characteristics of IL-4 and IL-13, their signaling pathways, and therapeutic antibodies against each cytokine as well as their receptors. In particular, the pleiotropic roles of IL-4 and IL-13 in orchestrating Th2 responses in AR and asthma patients indicate that dual IL-4/IL-13 blockade is a promising therapeutic strategy for both diseases.

【 授权许可】

CC BY