Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study

PeerJ

article

Yuyu Zhu¹  Shuman Tao¹  Danfeng Zhang¹  Jianping Xiao¹  Xuerong Wang¹  Liang Yuan¹  Haifeng Pan²  Deguang Wang¹ 

[1] Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hehei, Anhui Province;School of Public Health of Anhui Medical University, Hehei, Anhui Province

关键词: Fibrinogen/albumin ratio;    Coronary artery calcification;    Chronic kidney disease;   

DOI  :  10.7717/peerj.13550

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

AimPrevious studies have shown that the fibrinogen to albumin ratio (FAR) is closely related to the severity and prognosis of coronary atherosclerosis. In this study, we sought to evaluate the association between FAR and the degree of coronary artery calcification (CAC) in patients with chronic kidney disease (CKD).MethodsIn this retrospective study, 218 patients with CKD were stratified into low, medium and high FAR groups according to the tertiles of the FAR values. The CAC scores, clinical information and laboratory test results of the three FAR groups were compared. To explore the relationship between FAR and CAC we conducted binary logistic regression and correlation analyses.ResultsIn the low FAR group, the CAC scores were significantly lower than those in the medium and high FAR groups (P  <  0.001). There was a significant correlation between the FAR and CAC scores (r = 0.510, P  <  0.001). The FAR was an independent predictor of CAC (OR = 1.106, 95% CI [1.004–1.218], P = 0.042).ConclusionIn patients with CKD, the FAR can be considered as an effective predictor of CAC.

【 授权许可】

CC BY