A diagnostic model for overweight and obesity from untargeted urine metabolomics of soldiers

PeerJ

article

Exsal M. Albores-Mendez¹  Alexis D. Aguilera Hernández¹  Alejandra Melo-González¹  Marco A. Vargas-Hernández¹  Neptalí Gutierrez de la Cruz¹  Miguel A. Vazquez-Guzman¹  Melchor Castro-Marín¹  Pablo Romero-Morelos¹  Robert Winkler⁴ 

[1] Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea Mexicanos;Centro de Investigación en Ciencias de la Salud ,(CICSA), FCS, Universidad Anahuac Mexico, Campus Norte;Universidad Estatal del Valle de Ecatepec;UGA-Langebio;Biotechnology and Biochemistry

关键词: Metabolic status;    Metabolomics;    Military service;    Soldiers;    Public health;    Obesity;    Data mining;   

DOI  :  10.7717/peerj.13754

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Soldiers in active military service need optimal physical fitness for successfully carrying out their operations. Therefore, their health status is regularly checked by army doctors. These inspections include physical parameters such as the body-mass index (BMI), functional tests, and biochemical studies. If a medical exam reveals an individual’s excess weight, further examinations are made, and corrective actions for weight lowering are initiated. The collection of urine is non-invasive and therefore attractive for frequent metabolic screening. We compared the chemical profiles of urinary samples of 146 normal weight, excess weight, and obese soldiers of the Mexican Army, using untargeted metabolomics with liquid chromatography coupled to high-resolution mass spectrometry (LC-MS). In combination with data mining, statistical and metabolic pathway analyses suggest increased S-adenosyl-L-methionine (SAM) levels and changes of amino acid metabolites as important variables for overfeeding. We will use these potential biomarkers for the ongoing metabolic monitoring of soldiers in active service. In addition, after validation of our results, we will develop biochemical screening tests that are also suitable for civil applications.

【 授权许可】

CC BY