Insights on the evolution of Coronavirinae in general, and SARS-CoV-2 in particular, through innovative biocomputational resources

PeerJ

article

Daniel Andrés Dos Santos¹  María Celina Reynaga²  Juan Cruz González²  Gabriela Fontanarrosa²  María de Lourdes Gultemirian²  Agustina Novillo²  Virginia Abdala² 

[1] Cátedra de Bioestadística, Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán;Instituto de Biodiversidad Neotropical, Consejo Nacional de Investigaciones Científicas y Técnicas ,(CONICET) - Universidad Nacional de Tucumán;Cátedra de Química Inorgánica, Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán;Cátedra de Biología General y Metodología de las Ciencias, Facultadad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucumán

关键词: Coronavirus;    Host-virus interaction;    Chimerism;    Evolutionary constraints;    Virology;    Zoonotic reservoirs;    Viral proteomes;    Viral assembly;   

DOI  :  10.7717/peerj.13700

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

The structural proteins of coronaviruses portray critical information to address issues of classification, assembly constraints, and evolutionary pathways involving host shifts. We compiled 173 complete protein sequences from isolates belonging to the four genera of the subfamily Coronavirinae. We calculate a single matrix of viral distance as a linear combination of protein distances. The minimum spanning tree (MST) connecting the individuals captures the structure of their similarities. The MST re-capitulates the known phylogeny of Coronovirinae. Hosts were mapped onto the MST and we found a non-trivial concordance between host phylogeny and viral proteomic distance. We also study the chimerism in our dataset through computational simulations. We found evidence that structural units coming from loosely related hosts hardly give rise to feasible chimeras in nature. This work offers a fresh way to analyze features of SARS-CoV-2 and related viruses.

【 授权许可】

CC BY