Differential proteomic analysis of mouse cerebrums with high-fat diet (HFD)-induced hyperlipidemia

PeerJ

article

Changming Chen¹  Meiling Wen¹  Caixia Wang¹  Zhongwen Yuan²  Ya Jin¹ 

[1] Guangdong University of Technology, School of Biomedical and Pharmaceutical Sciences;The Third Clinical School of Guangzhou Medical University, Department of Pharmacy;Guangzhou Medical University, Key Laboratory for Major Obstetric Diseases of Guangdong Province

关键词: High-fat diet;    Hyperlipidemia;    Mouse;    Cerebrum;    Brain;    Lipid;    Proteomics;   

DOI  :  10.7717/peerj.13806

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

1.5 or <0.67, p < 0.05) in at least one of the four types of comparisons (left cerebrum hemispheres of the model group versus the control group, right cerebrums of model versus control, left cerebrums of SIM versus model, right cerebrums of SIM versus model). Biological process analysis revealed many of these proteins were enriched in the processes correlated with lipid metabolism, neurological disorders, synaptic events and nervous system development. For the first time, it has been reported that some of the proteins have been altered in the brain under the conditions of HFD feeding, obesity or hyperlipidemia. Further, 22 brain processes-related proteins showed different expression in the two cerebrum hemispheres, suggesting changes of the brain proteins caused by hyperlipidemia might also be asymmetric. We hope this work will provide useful information to understand the effects of HFD and hyperlipidemia on brain proteins.

【 授权许可】

CC BY