Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study

PeerJ

article

Yan Li¹  Qi Wan²  Zhixin Lan³  Ming Xia³  Haiyang Liu³  Guochun Chen³  Liyu He³  Chang Wang³  Hong Liu³ 

[1] Department of Nephrology, Hunan Provincial People’s Hospital, Hunan Normal University;Department of Orthopedic Surgery, The First Affiliated Hospital of Nanchang University;Department of Nephrology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification

关键词: Tonsillectomy;    IgA nephropathy;    Clinical remission;    Renal survival;    Indication;   

DOI  :  10.7717/peerj.14481

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundThe efficacy and indications of tonsillectomy in IgA nephropathy (IgAN) remain uncertain.MethodsWe performed a retrospective cohort study of 452 patients with primary IgAN, including 226 patients who received tonsillectomy and 226 controls selected by propensity score matching who had never undergone tonsillectomy. Study outcomes were clinical remission defined as negative hematuria and proteinuria on three consecutive visits over a 6-month period, the endpoint defined as end-stage renal disease or an irreversible 100% increase in serum creatinine from the baseline value. In addition, we further analyzed the critical level of proteinuria in the efficacy of tonsillectomy and the correlation between MEST-C score and tonsillectomy.Results1 g/24h, the clinical remission and renal survival rates were greater in patients treated with tonsillectomy than without. When the pathological damage was mild or relatively severe, tonsillectomy may be beneficial to clinical remission or renal survival.ConclusionsTonsillectomy had a favorable effect on clinical remission and delayed renal deterioration in IgAN. In addition to patients with early stage IgAN, it may also be beneficial to IgAN patients with higher levels of proteinuria and relatively severe pathological damage.

【 授权许可】

CC BY