The impact of hypertension on the prognosis of patients with hypertrophic cardiomyopathy: a single-center retrospective study

PeerJ

article

Ziqiong Wang¹  Yi Zheng¹  Haiyan Ruan¹  Liying Li¹  Muxin Zhang¹  Linjia Duan¹  Sen He¹ 

[1] Department of Cardiology, West China Hospital of Sichuan University;Department of Cardiology, Hospital of Traditional Chinese Medicine;Department of Cardiology, First People’s Hospital

关键词: Hypertrophic cardiomyopathy;    Hypertension;    Mortality;    Prognosis;   

DOI  :  10.7717/peerj.14614

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundHypertrophic cardiomyopathy (HCM) and hypertension coexist fairly frequently in clinical practice. However, the evidence about the impact of hypertension on the prognosis of HCM is limited. The present study aims to investigate the impact of hypertension on the prognosis of HCM patients.MethodsA total of 468 HCM patients were enrolled, and patients were divided into hypertension group (31.8%) and non-hypertension group (68.2%). The primary study endpoint was HCM-related death, consisting of heart failure (HF)-related death, stroke-related death and sudden cardiac death (SCD). Associations between hypertension and HCM-related death were analyzed by Cox regression models with the use of propensity score matching (PSM) as primary analysis.ResultsThere were 55 HCM-related death during a median follow-up time of 4.6 years, and the mortality rate was 2.53 per 100 person years. Kaplan-Meier analysis based on the crude cohort or PSM cohort revealed no significant difference regarding the HCM-related death between the two groups. In the crude cohort, both univariable and multivariable Cox regression analysis indicated that hypertension was not significantly associated with HCM-related death with hazard ratios (HR) at 0.74 (95% CI [0.40–1.36], p value: 0.329) and 0.77 (95% CI [0.35–1.71], p value: 0.521), respectively. Similarly, no strong evidence for an association was observed between hypertension and HCM-related death in the PSM cohort with unadjusted HR at 0.90 (95% CI [0.34–2.41]; p value: 0.838) and adjusted HR at 0.77 (95% CI [0.35–1.71]; p value: 0.521), respectively. Other propensity score methods, including overlap weighting and inverse probability treatment weighting demonstrated similar results. Sensitivity analysis also indicated that the concomitant hypertension did not significantly increase the risk of HF-related death, stroke-related death or SCD in HCM patients.ConclusionHCM-related death did not significantly differ between hypertension and non-hypertension groups, suggesting a negative impact of hypertension on the clinical prognosis of HCM patients.

【 授权许可】

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