Molecular subtypes, tumor microenvironment infiltration characterization and prognosis model based on cuproptosis in bladder cancer

PeerJ

article

Heping Zhang¹  Ji Liu²  Zongtai Zheng³ 

[1] Department of Oncology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University;Department of Urology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University;Department of Urology, Guangdong Second Provincial General Hospital

关键词: Cuproptosis;    Bladder cancer;    Tumor microenvironment;    Molecular subtypes;   

DOI  :  10.7717/peerj.15088

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Cuproptosis is a kind of cell death dependent on copper. We aimed to explore the functions of the cuproptosis in the tumor microenvironment (TME) and construct a cuproptosis-related prognosis signature in bladder cancer (BCa). Using BCa patients in the public cohort, the cuproptosis-related molecular subtypes and cuproptosis-related prognosis signature were developed. Three cuproptosis-related molecular subtypes, with different prognoses and TME characteristics, were identified in BCa. The cuproptosis-related prognosis signature can divide patients into high- and low-risk groups with different prognoses, TME characteristics, chemotherapeutic drug susceptibility and immunotherapeutic response. Low risk group patients had a favored prognosis and response to immunotherapy. The dysregulation of cuproptosis-related genes expression levels was validated in multiple BCa cells using in vitro experiments. Cuproptosis has an important role in the tumor progression and the characterization of TME in BCa. The cuproptosis-related prognosis signature is a useful biomarker that can reflect the prognosis, TME characteristics, immunotherapeutic response and chemotherapeutic drug susceptibility in BCa patients.

【 授权许可】

CC BY