Recent advances on natural depsidones: sources, biosynthesis, structure-activity relationship, and bioactivities

PeerJ

article

Maan T. Khayat¹  Kholoud F. Ghazawi²  Waad A. Samman³  Aisha A. Alhaddad³  Gamal A. Mohamed⁴  Sabrin RM Ibrahim⁵ 

[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University;Clinical Pharmacy Department, College of Pharmacy, Umm Al-Qura University;Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University;Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University;Department of Pharmacognosy, Faculty of Pharmacy, Assiut University;Department of Chemistry, Batterjee Medical College

关键词: Depsidones;    Lichens;    Fungi;    Biosynthesis;    Life on land;    Bioactivities;    Polyketides;    Drug discovery;   

DOI  :  10.7717/peerj.15394

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Depsidones are a class of polyphenolic polyketides that have been proposed to be biosynthesized from oxidative coupling of esters of two polyketidic benzoic acid derivatives. They are principally encountered in fungi and lichens. In addition to their diversified structural features, they revealed varied bioactivities such as antimicrobial, antimalarial, cytotoxic, anti-inflammatory, anti-Helicobacter pylori, antimycobacterial, antihypertensive, anti-diarrheal, antidiabetic, phytotoxic, anti-HIV, anti-osteoclastogenic, and butyrylcholinesterase, tyrosinase, hyaluronidase, and acetylcholinesterase inhibition. The current work was targeted to provide an overview on the naturally reported depsidones from various sources in the period from 2018 to the end of 2022 including their structures, biosynthesis, sources, and bioactivities, as well as the reported structure-activity relationship and semisynthetic derivatives. A total of 172 metabolites with 87 references were reviewed. The reported findings unambiguously demonstrated that these derivatives could be promising leads for therapeutic agents. However, further in-vivo evaluation of their potential biological properties and mechanistic investigations are needed.

【 授权许可】

CC BY