Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

PeerJ

article

Huiying Zhao¹  Xintong Li²  Yongqi Zheng³  Xiaofeng Zhu⁴  Xunzhong Qi⁵  Xinyan Huang⁶  Shunjie Bai⁷  Chengji Wu⁵  Guangtao Sun⁵ 

[1] Department of Neurology, Jiamusi University;Department of Neurology, The Third Affiliated Hospital of Shenzhen University;Department of Internal Medicine, Yichun Forestry Administration Central Hospital;Department of Neurology, Mudanjiang Medical College;Department of Neurology, The First Affiliated Hospital of Jiamusi University;Department of Neurology, The Second Affiliated Hospital of Jiamusi University;Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University

关键词: Astrocytes;    Alcohol;    Fasudil;    ROCK pathway;    Metabolomics;    Lipid metabolism;   

DOI  :  10.7717/peerj.15494

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for death, illness, and disability. Rho kinase inhibitors have neuroprotective effects. This study used metabonomics analysis to assess untreated astrocytes, astrocytes exposed to 75 mmol/L of alcohol, and astrocytes exposed to 75 mmol/L of alcohol and treated with 15 µg/mL fasudil for 24 h. One of the clearest differences between the alcohol-exposed and fasudil-treated alcohol-exposed groups was the abundance of lipids and lipid-like molecules, although glycerophospholipid metabolism was comparable in both groups. Our findings show that fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, providing a new approach for preventing and treating alcohol dependence.

【 授权许可】

CC BY