The link between lymphocyte subpopulations in peripheral blood and metabolic variables in patients with severe obesity

PeerJ

article

Tania Rivera-Carranza¹  Oralia Nájera-Medina²  Rafael Bojalil-Parra²  Carmen Paulina Rodríguez-López²  Eduardo Zúñiga-León³  Angélica León-Téllez Girón⁴  Alejandro Azaola-Espinosa³ 

[1] Universidad Autónoma Metropolitana;Department of Health Care, Metropolitan Autonomous University;Department of Biological Systems, Metropolitan Autonomous University;Division of Clinical Nutriology, Hospital General Dr. Manuel GEA González

关键词: Obesity;    Immunometabolism;    Body fat;    Memory T cells;    Effector T cells;   

DOI  :  10.7717/peerj.15465

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundObesity, a public health problem, is a state of metainflammation that influences the development of chronic degenerative diseases, particularly in patients with severe obesity.ObjectiveThe objective of this study was to evidence immunometabolic differences in patients with different degrees of obesity, including severe obesity, by determining correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables.MethodsPeripheral blood immune cells (CD4+, CD8+ memory and effector T lymphocytes) were analyzed, and measures of body composition, blood pressure, and biochemical composition (glucose, glycated hemoglobin (HbA1c), insulin, C-reactive protein (CRP), and the lipid profile) were carried out in patients with different degrees of obesity.ResultsThe patients were classified according to total body fat (TBF) percentage as normal body fat, class 1 and 2 obesity, class 3 obesity, and class 4 obesity. The greater the TBF percentage, the more pronounced the differences in body composition (such as a decrease in the fat-free mass (FFM) that is defined as sarcopenic obesity) and the immunometabolic profile. There was an increase of CD3+ T lymphocytes (mainly CD4+, CD4+CD62-, and CD8+CD45RO+ T lymphocytes) and an increase in the TBF percentage (severity of obesity).ConclusionsThe correlations between lymphocyte subpopulations and metabolic, body composition, and clinical variables demonstrated the existence of a chronic, low-intensity inflammatory process in obesity. Therefore, measuring the immunometabolic profile by means of lymphocyte subpopulations in patients with severe obesity could be useful to determine the severity of the disease and the increased risk of presenting obesity-associated chronic degenerative diseases.

【 授权许可】

CC BY