Saccharibacteria (TM7) , but not other bacterial taxa, are associated with childhood caries regardless of age in a South China population

PeerJ

article

Yang You¹  Meixiang Yin¹  Xiao Zheng¹  Qiuying Liang¹  Hui Zhang¹  Bu-Ling Wu³  Wenan Xu¹ 

[1] Department of Pediatric Dentistry, Shenzhen Stomatology Hospital ,(Pingshan), Southern Medical University;Department of Stomatology, Shenzhen Samii Medical Center;Department of Endodontics, Shenzhen Stomatology Hospital ,(Pingshan), Southern Medical University

关键词: Saccharibacteria;    Childhood caries;    16S rRNA;    Saliva;    Plaque;    Microbiota;   

DOI  :  10.7717/peerj.15605

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Human microbiome dysbiosis is related to various human diseases, and identifying robust and consistent biomarkers that apply in different populations is a key challenge. This challenge arises when identifying key microbial markers of childhood caries. Methods We analyzed unstimulated saliva and supragingival plaque samples from children of different ages and sexes, performed 16S rRNA gene sequencing, and sought to identify whether consistent markers exist among subpopulations by using a multivariate linear regression model. Results We found that Acinetobacter and Clostridiales bacterial taxa were associated with caries in plaque and saliva, respectively, while Firmicutes and Clostridia were found in plaque isolated from children of different ages in preschool and school. These identified bacterial markers largely differ between different populations, leaving only Saccharibacteria as a significant caries-associated phylum in children. Saccharibacteria is a newly identified phylum, and our taxonomic assignment database could not be used to identify its specific genus. Conclusion Our data indicated that, in a South China population, oral microbial signatures for dental caries show age and sex differences, but Saccharibacteria might be a consistent signal and worth further investigation, considering the lack of research on this microbe.

【 授权许可】

CC BY