Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China

PeerJ

article

Xueping Huang¹  Baihe Wu³  Qiuzhao Chen⁴  Yushan Chen⁵  Xinhua Ji⁶  Xiang Zhou⁶  Biao Suo⁴  Zhihui Lin¹  Xiaoling Zheng⁷ 

[1] Department of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University;Department of Gastroenterology, Fujian Provincial Hospital;Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University;Department of Gastroenterology, Xiamen Hospital of Traditional Chinese Medicine;Department of Gastroenterology, Fuzhou No.1 Hospital Affiliated with Fujian Medical University;Department of Gastroenterology, Pucheng Hospital;Department of Digestive Endoscopy, Shengli Clinical Medical College of Fujian Medical University;Department of Digestive Endoscopy, Fujian Provincial Hospital

关键词: Helicobacter pylori;    Antibiotic resistance;    Multicenter study;    Fujian;    China;   

DOI  :  10.7717/peerj.15611

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background and aim Efficacy of Helicobacter pylori (H. pylori) eradication is related to the local antimicrobial resistance epidemiology. We aimed to investigate the antibiotic resistance of H. pylori in Fujian, China. Methods H. pylori-infected patients in four centers were enrolled in the study from Oct 2019 to Jan 2022. The bacteria were isolated, cultured and identified from the biopsy of patients’ gastric mucosa samples. Antimicrobial susceptibility testing was performed by a modified broth microdilution method for H. pylori to seven guideline-recommended antibiotics and seven potential choices for H. pylori eradication. Results A total of 205 H. pylori strains were isolated. The resistance rates of amoxicillin (AMX), amoxicillin and clavulanate potassium (AMC), cefixime (CFM), gentamicin (GEN), tetracycline (TET), doxycycline (DOX), azithromycin (AZM), clarithromycin (CLR), levofloxacin (LVFX), sparfloxacin (SPFX), metronidazole (MTZ), tinidazole (TID), rifampicin (RFP) and furazolidone (FZD) were 11.22%, 12.20%, 7.32%, 12.20%, 4.88%, 4.39%, 44.39%, 43.90%, 30.24%, 21.46%, 40.98%, 45.85%, 5.37% and 10.24%, respectively. The rates of pan-sensitivity, single, double, triple and multiple resistance for seven guideline-recommended antibiotics were 32.68%, 30.24%, 13.17%, 7.76%, and 14.15%, respectively. The main double-resistance patterns were CLR+MTZ (10/205, 5%) and CLR+LVFX (9/205, 4%). The main triple-resistance pattern was CLR+MTZ+ LVFX (15/205, 7%). Conclusions In Fujian, the prevalence of H. pylori resistance to AZM, CLR, LVFX, SPFX, MTZ, and TID was high, whereas that to AMX, AMC, GEN, CFM, TET, DOX, RFP and FZD was relatively low. CFM and DOX are promising new choices for H. pylori eradication.

【 授权许可】

CC BY