Rotational Thromboelastometry Reference Range during Pregnancy, Labor and Postpartum Period: A Systematic Review with Meta-Analysis

Journal of Obstetric Anaesthesia and Critical Care

article

Alexander M. Ronenson¹  Efim M. Shifman³  Aleksandr V. Kulikov⁴  Yu S. Raspopin⁵  Klaus Görlinger⁷  Alexander M. Ioscovich⁹  Galina P. Tikhova¹ 

[1] Federal State Budgetary Educational Institution of Higher Education Tver State Medical University of the Ministry of Health of Russia. St. Sovetskaya;E.M. Bakunina Regional Clinical Perinatal Centre. Peterburgskoe Highway;M.F. Vladimirskiy Moscow Regional Research Clinical Institute;Ural State Medical University. St. Repina;Institute of Postgraduate Education of the Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky. St. Partizana Zheleznyak;Krasnoyarsk Regional Clinical Center for the Protection of Mothers and Children”;Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen;Medical Department;Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem

关键词: Coagulopathy;    hemorrhage;    point-of-care testing;    pregnancy;    thromboelastometry;   

DOI  :  10.4103/JOACC.JOACC_21_22

学科分类：社会科学、人文和艺术（综合）

来源: Medknow

【 摘 要 】

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) have become increasingly popular for urgent assessment of the hemostasis system. Accordingly, TEG and ROTEM algorithms and their corresponding cut-off values are not interchangeable. ROTEM provides fast results (including validated early clot firmness parameters [A5 and A10]), that are easy to use, and the graphical display of the results is easy to interpret. ROTEM manufacturer, Tem Innovations GmbH (Munich, Germany), mentions in the user manual that the manufacturer has not set any strict reference values for INTEM, EXTEM, FIBTEM, APTEM, and NATEM in any patient population (including pregnant women) and that these values are highly variable in healthy subjects. To date, no systematic review assessing ROTEM parameters in pregnant, parturient, and postpartum women is available. With the increasing usage of ROTEM, we conducted this systematic review and meta-analysis to determine the reference values of ROTEM parameters in pregnant, parturient, and postpartum women compared with non-pregnant population.

【 授权许可】

CC BY-NC-SA