Evaluation of Positive Relation between ProInflammatory Cytokines and Malnourished Children: Eastern Uttar Pradesh-India

Annals of Medical and Health Sciences Research

article

Rinki Kumari¹  Sneh Shalini¹  Akansha Sisodia²  Anil Kumar³  Ajay Kumar Sahi⁴  GP Dubey⁵ 

[1] ITRC-ECD, Indian Council of Medical Research;Department of Pediatrics, Hind Institute of Medical Sciences;School of Engineering and Sciences, GD Goenka University;Department of Biomedical Engineering, and Sciences, Banaras Hindu University;Department of Advanced Centre for Traditional and Genomic Medicine, Banaras Hindu University

关键词: Malnutrition;    Interleukins;    Tumor necrosis factor-alpha;    C-reactiveprotein;   

DOI  :  10.54608.annalsmedical.2022.14

来源: Medknow

【 摘 要 】

Malnutrition affects more than 95.9% of population in developing nations, and it has a big impact on children's health and their development and also associated with high morbidity impact and it is linked with changes in immunological-cytokines. The researchers needed to look at pro-in lammatory mediators in both healthy and underweight children. The goal of present study was to ind and compare the levels of pro-in lammatory cytokines in the control (healthy) and malnourished children. A total of 151 children were involved in this study, including 96 malnourished children and 55 healthy children of identical age and gender. The clinical, demographic, and plasma levels of Interleukin-1beta (IL-1beta) and 6, Tumor Necrosis Factor-alpha (TNF-alpha) and C-Reactive Protein (CRP) of these subjects were all evaluated using an ELISA kit. When compared to healthy children, malnourished children experienced a considerable reduction in weight and Weight-for-Age Z score (WAZ). Furthermore, the levels of serum interleukin-1 (IL-1) (0.10 vs. 0.05) and serum Interleukin-6 (IL-6) (pg/ml), (1.5 vs. 1.6), TNF-alpha (pg/ml) (1.7 vs.1.8), and CRP (mg/l) (0.7 vs. 1.0) were signi icantly higher in the malnourished group compared to the control group. Pro-in lammatory cytokines (IL-1, Interleukin-6 (IL-6), TNFalpha and CRP were found at higher concentrations in the blood of malnourished children.

【 授权许可】

Unknown