Prevalence and outcome of cholelithiasis in children with sickle cell disease at King Saud Medical City, Saudi Arabia

Journal of Applied Hematology

article

Adel Homoud Almudaibigh¹  Fawaz Abdulaziz Alkasim¹  Eatidal Fathey Ghareeb¹ 

[1] Department of Pediatric Hematology/Oncology, Pediatrics Hospital

关键词: Cholelithiasis;    gallstones;    hepatobiliary;    sickle cell disease;   

DOI  :  10.4103/joah.joah_241_20

学科分类：社会科学、人文和艺术（综合）

来源: Medknow

【 摘 要 】

BACKGROUND: Sickle cell disease (SCD) is one of the common hereditary blood diseases in Saudi Arabia. The hepatobiliary system is one of the common organs to be affected either directly from the sickling process or indirectly as a result of chronic hemolysis and multiple blood transfusions. Cholelithiasis is one of the common complications of sickle cell anemia. OBJECTIVES: To assess the prevalence of cholelithiasis in children with SCD treated at King Saud Medical City (KSMC); Pediatric Hospital in Saudi Arabia and describe the outcome, management, and clinical profile of children with SCD and cholelithiasis. MATERIALS AND METHODS: This is a retrospective descriptive study conducted at a single tertiary health care center, KSMC, Pediatric Hospital, Riyadh from 2012 to 2019 on 277 patients aged <14 years. Medical records of all pediatric patients with SCD included in the study were identified and reviewed. RESULTS: From total of 277 patients, 87 (31.4%) had cholelithiasis. Forty three (49.4%) of them were female and 44 (50.6%) were male. From 87 patients who developed cholelithiasis, 15 patients aged <5 years old, 50 aged (5–10 years), and 22 aged >10 years. According to the genotype of sickle cell (SS), the occurrence of cholelithiasis were (75.9% in SS, 23% in S/BETA 0 and 1.1% in S/BETA+). The majority were symptomatic (59.8%) compared to asymptomatic (40.2%) and 26 patients (29.9%) were complicated. In our study, we found that complications for the gallstones were acute calcular cholecystitis, chronic cholecystitis, direct hyperbilirubinemia, transaminitis, and acute pancreatitis. CONCLUSION: The prevalence of cholelithiasis in our study was significant. The large majority of patients were symptomatic. Cholecystectomy must be strongly recommended in symptomatic patients.

【 授权许可】

CC BY-NC-SA