Report of three Bengali cases with Hemoglobin E variant in Najran

Journal of Applied Hematology

article

Mohamed Samir M. Khalil¹  Awad M Al-Qahtani²  Jobran M AlQahtani³  Mohamed Mahmoud El Khawanky⁴ 

[1] Department of Clinical Pathology, Faculty of Medicine, Assiut University;Department of Family and Community Medicine, College of Medicine, Najran University;Department of Pediatrics, College of Medicine, Najran University;Department of Cl. Hematopathology, College of Medicine, Najran University

关键词: Hemoglobin A2;    hemoglobin E;    high-performance liquid chromatography;    Kolkata;    variant;   

DOI  :  10.4103/joah.joah_132_20

学科分类：社会科学、人文和艺术（综合）

来源: Medknow

【 摘 要 】

INTRODUCTION: Differential diagnosis of hemoglobin (Hb) variants eluting in the A 2 window on high-performance liquid chromatography (HPLC) is of particular importance. Of particular importance is Hb E, which is the most common and the most significant variant. The aim of this study was to study a rare variant infrequently seen in our countries during the routine work. METHODS: Sixteen Bengali workers at Najran University Hospital, Saudi Arabia, came to the laboratory for routine investigation. CBC, routine blood chemistry, and Hb separation by HPLC were performed. RESULTS: Three cases out of 16 showed an abnormal Hb peaked on the A 2 window on HPLC consistent with the diagnosis of Hb E. Two of them had Hb E of 29.1% of each. The third case had Hb E around 86%. In addition, one case was consistent with β thalassemia trait had increased Hb A 2 of 5.7%. Five cases were borderline. CONCLUSION: HbE could be adequately differentiated from other Hb variants eluting in the A 2 window on HPLC by the percentage of the variant, its retention time, the mild clinical presentation, and the ethnic origin of the patient.

【 授权许可】

CC BY-NC-SA