Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Index as Predictors of Poor Outcome in Patients with Critical Limb Ischemia Treated with Remote Endarterectomy

Journal Of Cardiovascular Emergencies

article

Anca Alexandra Derșidan¹  Claudiu Constantin Ciucanu¹  Agatha Maria Ilioniu¹  Ionela Georgiana Bodiu¹  Carina Diana Covalcic¹  Ludovic Alexandru Szanto¹  Adrian Vasile Mureșan¹ 

[1] Clinic of Vascular Surgery, Emergency County Hospital;Department of Vascular Surgery, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology

关键词: neutrophil-to-lymphocyte ratio;    systemic inflammation index;    critical limb ischemia;    remote endarterectomy;    biomarkers;   

DOI  :  10.2478/jce-2022-0013

学科分类：社会科学、人文和艺术（综合）

来源: Walter de Gruyter GmbH

【 摘 要 】

Introduction: Severe ischemia occurring in the lower limbs represents the advanced stage of peripheral artery disease (PAD). Atherosclerosis and inflammatory markers have been intensively studied to identify prognostic tools with a role in the evolution of patients with PAD. The aim of this study is to demonstrate the predictive value of systemic inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and the systemic inflammation index (SII) in the prognosis of patients diagnosed with critical leg ischemia (CLI) undergoing infrainguinal surgical revascularization with remote endarterectomy. Materials and methods: This retrospective study included all patients admitted to the Vascular Surgery Clinic of the County Emergency Clinical Hospital of Târgu Mureș, Romania between January 2018 and December 2021, who had critical limb ischemia Leriche-Fontaine stage III and were treated with endarterectomy. Patients were divided into two groups based on the presence or absence of patency in the lower limbs at 12 months. Results: There was a higher baseline value of neutrophil count (p <0.0001), platelet count (p = 0.006), NLR and SII value (p <0.0001), as well as a lower value of lymphocyte count (p = 0.001) in the group without patency at 12 months.

【 授权许可】

CC BY-NC-ND