Clinical and biological study of rheumatoid arthritis influence on salivary biomarkers in patients with periodontal disease

Balkan Journal of Dental Medicine

article

Boatca Madalin¹  Hurjui Loredana¹  Rudnic Ioana¹  Nicolaiciuc Ovidiu¹  Martu Silvia¹ 

[1] UMPh, 'Gr.T.Popa', Faculty of Dental Medicine, Periodontology Department

关键词: Biomarkers;    Interleukin-1b;    Tumour Necrosis Factor-α;    Periodontal Disease;    Rheumatoid Arthritis;   

DOI  :  10.1515/bjdm-2015-0051

学科分类：社会科学、人文和艺术（综合）

来源: Walter de Gruyter GmbH

【 摘 要 】

Aim: The purpose was to identify if rheumatoid arthritis (RA) influenced levels of salivary biomarkers of periodontal disease. Methods: Biological assessments and periodontal examinations were performed in 15 patients with RA, 10 patients with chronic periodontitis and 11 healthy patients as controls. Unstimulated whole saliva samples were analysed for interleukin-lb (IL-1b) and tumour necrosis factor-α (TNF-α) concentrations. Results: The arthritis and healthy patients had significantly less oral disease than the periodontitis group but the arthritis group had significantly more sites bleeding on probing (BOP) than the control group. Salivary levels of IL-1b were significantly elevated in the periodontal disease group, and IL-1b was the only biomarker with significantly higher levels in the arthritis group compared with control group. Arthritis patients receiving anti- TNF-α antibody therapy had significantly lower IL-lb and TNF-α levels compared with arthritis patients not on the anti-TNF-α therapy and healthy controls, respectively. Conclusion: RA patients have higher levels of periodontal inflammation than healthy control group and also an increased BOP. Systemic inflammation appears to influence levels of selected salivary biomarkers of periodontal disease, and anti-TNF-α therapy significantly modified lowered salivary levels IL-lb and TNF-α levels in RA.

【 授权许可】

CC BY