Excitements in Radiobiology

Journal of Radiation and Cancer Research

article

Mishra, K. P.¹ 

[1] Ex-Head, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Center

关键词: Chemotherapy–radiotherapy;    dysphagia;    external beam radiotherapy;    esophagus;    high-dose rate;    intraluminal brachytherapy;   

DOI  :  10.4103/jrcr.jrcr_45_21

学科分类：药学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Aim:  The purpose of this study is to compare local tumor control, dysphagia-free survival, and complication in patients with locally advanced carcinoma esophagus using external beam radiotherapy (EBRT) alone (Arm A) and EBRT followed by intraluminal brachytherapy (ILBT) (Arm B). Materials and Methods:  A total of 50 histopathologically proven patients of locally advanced unresectable cancer esophagus were taken for the study from March 2019 to February 2020 and were divided into two arms, 25 patients each. Arm A was treated by standard concurrent chemotherapy–radiotherapy (CTRT) alone (a total dose of 50 Gray (Gy) in 25 fractions (fr), 2 Gy/fr administered daily 5 days per week with weekly injection cisplatin 40 mg/m2) and Arm B received 44 Gy through two definitive radiation therapies along with computed tomography followed by ILBT (5 Gy/fr; 2 fr 1 week apart). Assessment was done weekly during RT and 3 and 6 months post treatment for local control of disease and dysphagia-free survival and complication. Results:  The local tumor control was observed 80% and 84% at 6 months in Arm A and Arm B, respectively (P = 0.82). Six-month dysphagia-free survival was 52% versus 68% (P = 0.248) and stricture formation was found 16% and 24% (P = 0.479) in Arm A and Arm B, respectively. Conclusion:  This study shows comparable results of CTRT-ILBT over CTRT alone in locally advanced esophageal cancer patients.

【 授权许可】

CC BY-NC-SA