Immune Response against Hepatitis B Vaccine in Transfusion-Dependent Thalassemic Children Vaccinated in Early Infancy

Global Journal of Transfusion Medicine

article

Hossain, Fatema¹  Khatun, Ayesha²  Islam, Ashadul²  Miah, Sonia Shormin²  Saha, Subarna²  Tanni, Nusrat Noor¹ 

[1] Department of Transfusion Medicine, National Institute of Diseases of the Chest and Hospital;Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University

关键词: Blood donation;    blood donors;    counseling;    sexually transmitted diseases;    syphilis;    Treponema pallidum;   

DOI  :  10.4103/gjtm.gjtm_45_22

学科分类：社会科学、人文和艺术（综合）

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Background and Objectives:  An increasing prevalence of sexually transmitted infections especially Syphilis in blood donors may lead to increased donor deferrals and lessen the donor pool. Hence it is the need of the hour to device a structured screening methodology for Syphilis reactive donors. The aim of the study is to estimate the prevalence of syphilis in blood donors and to estimate the response rate of notified blood donors. Patients and Methods:  This was a retrospective study, conducted in a Blood Centre (BC) on the blood donors visiting for donation from January 2020 to September 2021. The donors screened positive on chemiluminescence immunoassay were included after informed consent was obtained, and donor demographics and follow-up response rate were analyzed. Frequency and percentages were used to express descriptive statistics and Chi-square was used to test the relationship between categories (p<0.05 considered significant). Results:  Out of 26,698 donations during the study period, 133 donors were screened positive for syphilis. 127 (96%) donors consented to postdonation. Out of 127, only 61 were notified regarding the infection and were advised about further followup. 52% of the donors who consented to postdonation counseling were not notified due to erroneous contact details. Out of 46 responders, only 17 underwent further testing. Conclusions:  The prevalence rate of syphilis was found to be 0.49%. Among the donors notified, 75% responded back to the BC. Due to social stigma and inadequate knowledge about the disease, often, donors are hesitant to give a reliable exposure history. Adequate education and adapting to a structured screening methodology is the need of the hour to reduce the risk of transfusion-transmitted syphilis.

【 授权许可】

CC BY-NC-SA