Neuroprotective effect of electroacupuncture against acute ischemic stroke via PI3K-Akt-mTOR pathway-mediated autophagy

World Journal of Traditional Chinese Medicine

article

Velika Yovitania¹  Qin-Hui Fu²  Jian Pei²  Hua Zhou³ 

[1] Department of Acupuncture, Longhua Hospital, Faculty of Acupuncture, Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine;Department of Acupuncture, Longhua Hospital, Shanghai University of Traditional Chinese Medicine;Faculty of Chinese Medicine and State key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology

关键词: Acupuncture;    autophagy;    ischemic stroke;    nerve regeneration;    neuroprotection;   

DOI  :  10.4103/2311-8571.333712

学科分类：内科医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Acupuncture has been used to treat ischemic stroke, and mounting evidence demonstrates the neuroprotective and autophagy-mediated actions of electroacupuncture (EA). This review summarizes the evidence that EA affects different stages of autophagy, its neuroprotective action, and effects of different acupoints in treating ischemic stroke. Systematic searches were conducted on English and Chinese databases (MEDLINE, Elsevier, ScienceDirect, Cochrane Library, and China National Knowledge Infrastructure). Studies published up until February 2021 were considered for inclusion, and a final of fifty articles were included in this review. There is evidence that acupuncture promotes neuroprotection by modulating autophagy, and the treatment effectiveness is related to the acupoint selection and timing of treatment administration.

【 授权许可】

CC BY-NC-SA