The fruits of Xanthium sibiricum Patr : A review on phytochemistry, pharmacological activities, and toxicity

World Journal of Traditional Chinese Medicine

article

Hai Jiang¹  Xue-jiao Wang¹  Liu Yang¹  Jia-Xu Zhang¹  A-Jiao Hou¹  Wen-Jing Man¹  Song Wang¹  Bing-You Yang¹  Kelvin Chan²  Qiu-Hong Wang³  Hai-Xue Kuang¹ 

[1] Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University;Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, School of Traditional Chinese Medicine, Guangdong Pharmaceutical University

关键词: Pharmacological activities;    phytochemistry;    toxicity;    Xanthii Fructus;   

DOI  :  10.4103/wjtcm.wjtcm_49_20

学科分类：内科医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

In recent years, drug development and research have gradually shifted from chemical synthesis to biopharmaceutical and natural drugs. Natural medicines, such as traditional Chinese medicine, have been among the first studied because of their long medicinal history, simplicity, and the relatively low cost of research. Among them, Xanthii Fructus (XF) is famous for the treatment of sinusitis. In this article, the achievements of research on XF from 1953 to 2020 are systematically reviewed, focusing on the aspects of chemical constituents, pharmacological effects, clinical applications, toxicity and side effects, and processing methods. To date, there have been significant advances in both the phytochemistry and pharmacology of XF. Some traditional uses have been validated and clarified in modern pharmacological studies. However, its mechanism of action in the treatment of allergic diseases has not been satisfactorily explained. Further in vitro and in vivo studies are required to rationally develop new drugs and to elucidate the therapeutic potential of XF. A comprehensive evaluation of XF and an understanding of network pharmacology are also needed.

【 授权许可】

CC BY-NC-SA