Clinical effect of tripterygium glycosides combined with glucocorticoids in the treatment of refractory nephrotic syndrome patients: A systematic review and meta-analysis

World Journal of Traditional Chinese Medicine

article

Ya-Qing Cheng¹  Jing Li¹  Hai-Shun Qu¹  Xian-Zhi Zhang¹  Hai-Li Zhang¹  Jing Zhang¹  Bo Peng² 

[1] Department of Nephroendocrine, Dongzhimen Hospital of Beijing University of Chinese Medicine;Department of State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau

关键词: Glucocorticoids;    meta-analysis;    refractory nephrotic syndrome;    Tripterygium glycosides;   

DOI  :  10.4103/wjtcm.wjtcm_20_20

学科分类：内科医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

The objective of this study is to evaluate the effectiveness and safety of Tripterygium glycosides combined with glucocorticoids for the treatment of refractory nephrotic syndrome (NS). Computer search of Chinese and English databases, including CNKI, VIP, Wan Fang Database, PubMed, Cochrane Library, Embase, and Sinomed, for randomized controlled trials (RCTs) of Tripterygium glycosides combined with glucocorticoids for refractory NS (RNS) was conducted. Meta-analysis was performed using RevMan5.3. Thirteen RCTs comprising 994 patients were included in the study. Tripterygium glycosides combined with glucocorticoids had a statistical significance on the effective rate (odds ratio [OR] =4.69, 95% confidence interval [CI] 3.29, 6.67, P < 0.00001), 24-h urine protein ( Weighted mean difference (MD) = −0.57, 95% CI [−0.62, −0.51], P < 0.00001), serum albumin (MD = 4.77,95% CI [4.30, 5.24], P < 0.00001), total serum protein (MD = 9.45, 95% CI [8.73, 10.17], P < 0.00001), urea nitrogen (MD = −0.53, 95% CI [−0.90, −0.17], P = 0.005), and serum creatinine (MD = −8.45, 95% CI [−15.32, −1.57], P = 0.02). There was no statistical significance on adverse reactions (OR = 0.68, 95% CI [0.41, 1.12], P = 0.13). Tripterygium glycosides combined with glucocorticoids could improve clinical effective rate, reduce 24-h urine protein, improve serum albumin and total serum protein, and reduce urea nitrogen and serum creatinine levels in patients with RNS. However, the quality of the included literature is poor, and conclusion still needs further verification using larger samples and high-quality randomized, double-blind controlled trials.

【 授权许可】

CC BY-NC-SA