Protein kinase inhibitors affect spermatogenic functions and blood testis barrier remodelling: A scoping review

Asian Pacific Journal of Reproduction

article

Obukohwo, Oyovwi Mega¹  Oghenetega, Onome Bright²  Faith, Falajiki Yewande¹  Victor, Emojevwe³  Rume, Rotu Arientare⁴  Uchechukwu, Joseph Gregory⁵  Abioye, Oyeleke Abiodun¹ 

[1] Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University;Department of Physiology, School of Basic Medical Science, Babcock University;Department of Physiology, University of Medical Sciences;Department of Physiology, University of Ibadan;Department of Medical Laboratory Science, Adeleke University

关键词: Spermatogenesis;    Protein kinase;    Inhibitors;    Sertoli cells;    Capacitation;    mTOR;   

DOI  :  10.4103/2305-0500.377500

学科分类：兽医学

来源: Wolters Kluwer Medknow Publications

【 摘 要 】

Objective:  To identify the role of protein kinase in male reproduction in animal models and human spermatogenic function. Methods:  This study assessed the protein kinase of male reproduction in animal models and human using different reviewed paper indexed in PubMed, Science Direct, EBSCO, Scopus, Cochrane Library, Sage Journals, and Google Scholar. Data were charted based on author, year of publication published between 1893 and 2023, country, purpose, data collection, key findings, and research focus/domain. Results:  The MAPK pathway contributed to the growth, maturation, and functionality of male germ cells. We also found out that certain influencing factors categorized into hormonal/non hormonal factors and chemotoxicant, as well as heat stress expressed an inhibitory mechanism on protein kinase, thus affecting spermatogenic functions and maintenance/remodeling of the blood testis barrier, as well as the physiology of the Sertoli cells necessary for nutritional support of spermatogenesis. However, activating protein kinases pathway like the mTOR pathway as well as increased expression of peroxiredoxin-4 and L-carnitine mediated protein kinases may be useful for treating or managing male reproductive dysfunction. Conclusions:  Protein kinase plays an important role in spermatogenic functions and blood testis remodeling in animal and human. Its assessment provides essential information that can guide treatment strategies aimed at improving male reproductive potential. Taken together, these recent advances highlight a future therapeutic intervention in assessing male reproductive potential. It might also be possible to look at potential targets for male contraceptives in the MAPK pathway.

【 授权许可】

CC BY-NC-SA